TABLE 3.

Univariable and multivariable Cox regression analysis of factors associated with DR in gastric cancer patients treated with preoperative chemotherapy and CXRT.

Univariable
Variable	HR (95% CI)	P value
TRG		0.025
0 (ref)	ref
1	1.55 (0.69–3.49)	0.292
2	1.89 (0.93–3.82)	0.077
3	3.04 (1.43–6.46)	0.004
ypN status (ypN+ vs. ypN-)	3.20 (2.05–4.99)	<0.001
ypT category		<0.001
0	1.13 (0.43–2.96)	0.811
1 (ref)	ref
2	1.48 (0.59–3.71)	0.403
3	2.95 (1.31–6.63)	0.009
4a/b	6.12 (2.42–15.47)	<0.001
Age at diagnosis (≥65 vs. <65 years)	0.74 (0.45–1.21)	0.233
Sex (female vs. male)	1.05 (0.67–1.64)	0.837
Race/ethnicity		0.723
White (ref)	ref
Black	0.76 (0.33–1.78)	0.527
Asian	0.74 (0.42–1.30)	0.293
Hispanic	0.89 (0.44–1.82)	0.757
Tumor location		0.223
Gastroesophageal junction	ref
Cardia/fundus	0.62 (0.21–1.78)	0.371
Body	0.84 (0.48–1.45)	0.525
Antrum	1.08 (0.58–2.01)	0.820
Total	2.21 (0.89–5.45)	0.087
Tumor histology		0.616
Moderately differentiated	ref
Poorly differentiated	0.85 (0.50–1.44)	0.542
Unknown	0.64 (0.25–1.60)	0.336
Signet ring cell features (yes vs. no)	1.44 (0.92–2.25)	0.110
Linitis plastica (yes/suspected vs. no)	2.99 (1.70–5.28)	<0.001
Concomitant organ resection	1.54 (0.90–2.64)	0.113
Adjuvant therapy (yes vs. no)	1.07 (0.34–3.39)	0.909
Number of lymph nodes examined <16	0.81 (0.51–1.30)	0.386
Extent of lymph node dissection		0.237
D0/D1	Ref
D1+/D2	0.65 (0.34–1.23)	0.185
Unknown	2.01 (0.26–15.58)	0.505
R1 resection	2.53 (1.21–5.28)	0.014
ypM1 status	7.38 (3.36–16.19)	<0.001
Type of resection		0.264
Total gastrectomy	ref
Subtotal gastrectomy	0.67 (0.42–1.10)
Proximal gastrectomy	0.71 (0.26–1.96)
Multivariable
Variable	HR (95% CI)	P value
TRG		0.851
0 (ref)	Ref
1	1.01 (0.44–2.35)
2	1.21 (0.58–2.54)
3	1.33 (0.58–3.06)
ypN status (ypN+ vs. ypN-)	2.44 (1.34–4.45)	0.004
Linitis plastica (yes/suspected vs. no)	2.90 (1.79–4.69)	<0.001
R1 resection	1.73 (0.80–378)	0.167