. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: Cancer Res. 2020 Jun 17;80(17):3755–3764. doi: 10.1158/0008-5472.CAN-20-0093

Table 2 |.

Genome-wide significant loci on chromosome 7q21.3 for sperm concentration and their results in independent replication samples

			Discovery sample (n=167)				Primary replication sample (n=34)			Secondary replication sample (n=24)

SNP	BP	MA/OA	MAF	Crude mean sperm concentration (OO/OM/MM)	Change in sperm concentration, million/mL (95% CI)	P	MAF	Change in sperm concentration, million/mL (95% CI)	P	MAF	Change in sperm concentration, million/mL (95% CI)	P
rs2237572	92630946	C/T	0.21	21.93/51.28/86.71	38.45 (25.44,51.46)	4.2×10⁻⁸	0.16	−73.51 (−183.60,36.58)	0.22	0.26	−0.22 (−13.31,12.86)	0.974
rs10225965	92644264	T/C	0.20	21.52/53.22/86.71	39.14 (26.25,52.03)	1.9×10⁻⁸	0.16	−73.51 (−183.60,36.58)	0.22	0.24	0.80 (−13.11,14.70)	0.912
rs7784118	97627780	A/G	0.28	52.26/17.99/6.00	−37.30 (−49.83,−24.77)	3.5×10⁻⁸	0.34	−73.27 (−99.97,−46.58)	3.1×10⁻⁴	0.36	−14.88 (−25.11,−4.64)	0.012

Chr, chromosome; Genomic positions are shown relative to GRCh38 (hg38); MA, minor allele; OA, other (major) allele; MAF, minor allele frequency; OO, survivors homozygous for other allele; OM, survivors with heterozygote genotypes; MM, survivors homozygous for the minor allele; CI, confidence interval