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Simplified image displaying the results of TGF-β-induced CTGF expression mediated via the ERK/ADAM17/RSK1/C/EBPβ pathway in human lung epithelial cells. TGF-β activated the ERK/ADAM17/RSK1/C/EBPβ signaling pathway, which in turn initiates binding of C/EBPβ to the CTGF promoter and ultimately induces CTGF expression in human lung epithelial cells. Moreover, ADAM17 and CTGF participated in TGF-β-induced FN expression.
