. 2020 Dec 7;25(23):5773. doi: 10.3390/molecules25235773

Table 1.

Inhibition data of new isatin derivatives 18–20 and 23–26.

graphic file with name molecules-25-05773-i001.jpg

Comp.	R	R₁	R₂	Aβ₄₀ Aggregation Inhibition
Comp.	R	R₁	R₂	% at 100 μM	IC₅₀ (μM)
18	5-OCH₃				1.3 ± 0.1
19	5-OH				1.6 ± 0.3
20	5-OH			26 ± 3
23	H	H			4.8 ± 0.5
24	H	H			10 ± 2
25	H	H		63 ± 5
26	5-OCH₃	H		12 ± 5
1					0.43 ^a
Quercetin					0.82 ^a

^a Data taken from [17]. Values are mean ± SEM (n = 3).