Skip to main content
. 2020 Dec 7;25(23):5773. doi: 10.3390/molecules25235773

Table 5.

Inhibition of β-amyloid and tau aggregation.

Code Structure Aβ40 Inhibition Tau Inhibition a
% at 100 μM IC50 (μM) % at 10 μM IC50 (μM)
S22 b graphic file with name molecules-25-05773-i031.jpg -c 15 ± 3
S23 b graphic file with name molecules-25-05773-i032.jpg 52 7.7 ± 1.0
S34 b graphic file with name molecules-25-05773-i033.jpg 20 16 ± 2
S35 b graphic file with name molecules-25-05773-i034.jpg 44 10 ± 2
4 graphic file with name molecules-25-05773-i035.jpg 31 ± 3 17 ± 2
5 graphic file with name molecules-25-05773-i036.jpg 22 ± 2 4.6 ± 0.7
6 graphic file with name molecules-25-05773-i037.jpg 45 ± 6 14 ± 2
7 graphic file with name molecules-25-05773-i038.jpg 2.0 ± 0.3 19 ± 2
8 graphic file with name molecules-25-05773-i039.jpg 69 ± 3 35 ± 2
9 graphic file with name molecules-25-05773-i040.jpg 0.95 ± 0.04 20 ± 2

a From cell-based assay. b Compounds and their data of β-amyloid aggregation are taken from ref. [16] and presented in Supplementary Materials. Values are mean ± SEM (n = 3) in in vitro assay. c No inhibition at 100 μM concentration.