Table 6.

Inhibition data of acetylcholinesterase and monoamine oxidases.

Comp.	hAChE a		hMAO A a		hMAO B a
	% Inhib. at 10 μM	IC50 (μM)	% Inhib. at 10 μM	IC50 (μM)	% Inhib. at 10 μM	IC50 (μM)
5	37 ± 1			0.52 ± 0.04		3.6 ± 0.7
6		4.2 ± 0.8	23 ± 5		22 ± 4
7	48 ± 3		29 ± 3		41 ± 1
8		3.9 ± 0.5	8 ± 3		36 ± 4
9	48 ± 2		15 ± 3			4.0 ± 0.4
18	23 ± 1		31 ± 4		47 ± 2
19	31 ± 1		18 ± 4		46 ± 5
23	40 ± 3			7.1 ± 0.3		5.3 ± 0.3
11	47 ± 5		20 ± 4			2.7 ± 0.3
13	26 ± 1		7 ± 2			4.4 ± 0.1
32	41 ± 5			0.34 ± 0.01		0.23 ± 0.03
35	38 ± 2			3.8 ± 0.3		6.5 ± 0.6
Galantamine		0.72 ± 0.05	-	-	-	-
Safinamide	-	-	18 ± 3			0.031 ± 0.001

^a Human recombinant enzymes. Values are mean ± SEM (n = 3).