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. 2020 Dec 3;21(23):9209. doi: 10.3390/ijms21239209

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of the treatment with carvone enantiomers on allergic sensitization. BALB/c mice were orally pre-treated with R-carvone (10 mg/Kg) or S-carvone (10 mg/Kg) 1 h before each sensitization. (A) Eosinophils per BAL counted under light microscopy and (B) Titers of OVA-specific IgE in the serum were assessed using the PCA test 24 h after the last OVA-challenge. Results are expressed as means ± SEM and are representative of two independent experiments performed with 6–8 animals per group. + significant difference (p < 0.05) from the unchallenged group; *** significant difference (p < 0.001) from the untreated OVA-challenged group. Statistical significance was determined with one-way ANOVA and post hoc Tukey test.