Figure 2.

The loss in eGFR in patients who started TDF-containing ART relative to non-TDF containing ART: results from two Asian studies and one study from Canada. Whereas two studies from Asia (Joshi et al. and Nishijima et al.) showed that the loss in eGFR among the patients who started TDF containing ART relative to those who started non-TDF containing ART continued to increase over time, the study from Canada (Laprise et al.) showed that most of the loss in eGFR was acquired during the first year of exposure and stabilized after that (15,20,41). eGFR, estimated glomerular filtration rate; ART, antiretroviral therapy; TDF, tenofovir disoproxil fumarate.