Table 3.

REACTOME over-representation results. Entities Found: differentially modulated proteins between RAOM and ATH found belonging to the pathway/total proteins belonging to the pathway. Ratio: numerical ratio between differentially modulated proteins between RAOM and ATH found belonging to the pathway/total proteins belonging to the pathway. p-value: The result of the Binomial Test for over-representation. FDR: False Discovery Rate, Corrected over-representation probability.

Pathway Name	Entities Found	Ratio	p-Value	FDR
Neutrophil degranulation	7/480	0.023	9.40 × 10−5	0.06
Glycolysis	4/124	0.006	1.80 × 10−4	0.06
Glucose metabolism	4/197	0.009	0.001	0.226
Hh mutants that don′t undergo autocatalytic processing are degraded by ERAD	2/63	0.003	0.009	0.402
Hh mutants abrogate ligand secretion	2/67	0.003	0.01	0.402
Chaperone Mediated Autophagy	3/200	0.01	0.01	0.402
HSF1 activation	2/79	0.004	0.014	0.402
Role of ABL in ROBO-SLIT signaling	1/10	4.78 × 10−4	0.022	0.402
Late endosomal microautophagy	2/109	0.005	0.025	0.402
Post-translational protein phosphorylation	2/109	0.005	0.025	0.402