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. 2020 Nov 30;21(23):9106. doi: 10.3390/ijms21239106

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Epigenetic regulation of bovine uterine inflammatory diseases. (A). Macroscopic view—Comparison of a healthy and endometritis infected bovine reproductive system Endometritis is defined as a localized infection of the uterus lining [107]. (B). Microscopic view—Transcribed miRNA precursor (pre-miRNA) transfer to the cellular cytoplasm before mature miRNA targets the 3′ untranslated region (UTR) of specific mRNA. The inactive complex of (miRNA-mRNA) repress the translation process and the fate of mRNA is to be degraded. This may result in inflammatory diseases such as endometritis and poor fertility. For example, miR-218 has shown to be involved in the pathogenesis of bovine endometritis by inhibiting the activating mRNA of macrophage inflammatory protein (Mip-1) chemokine [108].