Table 1.
Salicylates with their structures and targeted protein.
| Salicylates & Structure | Proteins | References |
|---|---|---|
| Salicylic acid | Ferrochelatase (FECH) | [16] |
|
Cyclin-dependent kinase 2 (CDK2) | [14] |
| α-Enolase (ENO1) | [20] | |
| Pyruvate kinase isozyme M2 (PKM2) | [20] | |
| Acetylsalicylic acid (Aspirin) | Cyclooxygenase-1 (COX-1) | [21,22] |
|
Cyclooxygenase-2 (COX-2) | [18,21,22] |
| Nuclear factor-kappaB (NF-κB) | [11] | |
| Cathepsin A (CTSA) | [12] | |
| Inhibitor of nuclear factorkappa-B kinase subunit beta (Iκκ-β) | [23] | |
| Ribosomal S6 kinase 2 (RSK2) | [13] | |
| Cyclin-dependent kinase 2 (CDK2) | [14] | |
| 5-aminosalicylic acid (Mesalazine) | Arachidonate 5-lipoxygenase (ALOX5) | [15] |
|
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) | [16] |
| 2-(2-hydroxybenzoyl) oxybenzoic acid (Salsalate) | Acetyltransferase p300 (P300) | [24] |
| ||
| Acetyl 3-aminoethyl salicylic acid (Ac3AESA) | Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) | [16] |
|
High mobility group box 1 (HMGB1) | [19] |
| 2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl) sulfamoyl] phenyl} diazen-1-yl] benzoic acid (Sulfasalazine) | Tumor necrosis factor alpha (TNFα) | [17] |
|
Arachidonate 5-lipoxygenase (ALOX5) | [15] |
| Sodium salicylate | Cyclooxygenase-2 (COX-2) | [18,21,22] |
|
Nuclear factor-kappaB(NF-κB) | [11] |
| Inhibitor of nuclear factorkappa-B kinase subunit beta (Iκκ-β) | [23] |