Table 3. Univariate and multivariate analysis of overall survival.
| Variables | Univariate Analysis |
Multivariate Analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Patient factors | ||||||
| Sex, | ||||||
| Male / Female | 1.11 | 0.20-20.6 | 0.918 | |||
| Age | ||||||
| ≥ 70 years / ≤ 69 years | 1.21 | 0.36-3.86 | 0.756 | |||
| BMI | ||||||
| ≥ 25.0 kg/m2 / ≤ 24.9 kg/m2 | 1.23 | 0.55-2.75 | 0.684 | |||
| ASA | ||||||
| ≥ 2 / ≤ 1 | 0.60 | 0.21-1.45 | 0.183 | |||
| AFP | ||||||
| ≥ 9.0 IU/mL / ≤ 8.9 IU/mL | 0.41 | 0.06-1.80 | 0.251 | |||
| CEA | ||||||
| ≥ 5.0 IU/mL / ≤ 4.9 IU/mL | 0.88 | 0.19-2.75 | 0.787 | |||
| CA19-9 | ||||||
| ≥ 37.0 IU/mL / ≤ 36.9 IU/mL | 0.91 | 0.19-3.40 | 0.902 | |||
| Preoperative chemotherapy | 0.91 | 0.31-2.48 | 0.924 | |||
| Primary cancer-related factors | ||||||
| Tumor location | ||||||
| EGJ, Upper / Middle, Lower | 1.78 | 0.55-4.84 | 0.314 | |||
| Maximum primary tumor size | ||||||
| ≥ 5 cm / ≤ 4.9 cm | 1.72 | 0.59-5.52 | 0.312 | |||
| T classification | ||||||
| ≥ 3 / ≤ 2 | 1.17 | 0.73-2.94 | 0.240 | |||
| N classification | ||||||
| ≥ 1 / ≤ 0 | 1.35 | 0.50-3.94 | 0.552 | |||
| Histological type | ||||||
| Intestinal / Diffuse and other | 0.26 | 0.08-0.85 | 0.027 | 0.24 | 0.07-0.81 | 0.022 |
| Liver metastases-related factors | ||||||
| Timing of liver metastases | ||||||
| Metachronous / Synchronous | 0.68 | 0.63-4.94 | 0.284 | |||
| Tumor number | ||||||
| Multiple / Single | 1.06 | 0.33-2.86 | 0.914 | |||
| Tumor distribution | ||||||
| Bilobular / Unilobular | 1.34 | 0.42-3.68 | 0.586 | |||
| Maximum tumor size | ||||||
| ≥ 5 cm / ≤ 4.9 cm | 0.66 | 0.15-2.09 | 0.518 | |||
| Operative procedures | ||||||
| Synchronous hepatectomy | 1.65 | 0.54-4.62 | 0.354 | |||
| Major hepatectomy | 3.43 | 1.09-44.7 | 0.044 | |||
| Operating time | ||||||
| ≥ 360 min / ≤ 359 min | 1.57 | 0.57-4.45 | 0.371 | |||
| Estimated blood loss | ||||||
| ≥ 1000 mL / ≤ 999 mL | 1.26 | 0.44-3.46 | 0.648 | |||
| Resection | ||||||
| ≥ R1 / R0 | 4.86 | 1.32-17.9 | 0.018 | 5.31 | 1.40-20.5 | 0.015 |
| Postoperative factors | ||||||
| Clavien-Dindo classification | ||||||
| ≥ I / ≤ 0 | 0.81 | 0.59-2.00 | 0.786 | |||
| Duration of hospital stay | ||||||
| ≥ 14 days / ≤ 13 days | 1.34 | 0.48-3.85 | 0.567 | |||
| Postoperative chemotherapy | 1.12 | 0.41-3.09 | 0.815 | |||
Abbreviations: BMI, body mass index; ASA, American society of anesthesiologists; AFP, α-fetoprotein; CEA, carcinoembryonic antigen; CA19- 9, carbohydrate antigen 19-9; EGJ, esophagogastric junction; Por, undifferentiated adenocarcinoma; HR, hazard ratios; CI, confidence intervals.