Table 4. Univariate and multivariate analysis of recurrence-free survival.
| Variables | Univariate Analysis |
Multivariate Analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Patient factors | ||||||
| Sex | ||||||
| Male / Female | 1.08 | 0.32-6.72 | 0.938 | |||
| Age | ||||||
| ≥ 70 years / ≤ 69 years | 1.02 | 0.41-2.59 | 0.949 | |||
| BMI | ||||||
| ≥ 25.0 kg/m2 / ≤ 24.9 kg/m2 | 0.73 | 0.38-1.30 | 0.307 | |||
| ASA | ||||||
| ≥ 2 / ≤ 1 | 0.91 | 0.28-2.20 | 0.460 | |||
| AFP | ||||||
| ≥ 9.0 IU/mL / ≤ 8.9 IU/mL | 1.68 | 0.54-5.09 | 0.356 | |||
| CEA | ||||||
| ≥ 5.0 IU/mL / ≤ 4.9 IU/mL | 4.88 | 0.53-4.85 | 0.447 | |||
| CA19-9 | ||||||
| ≥ 37.0 IU/mL / ≤ 36.9 IU/mL | 2.65 | 0.89-8.16 | 0.077 | |||
| Preoperative chemotherapy | 0.89 | 0.44-2.99 | 0.821 | |||
| Primary cancer-related factors | ||||||
| Tumor location | ||||||
| EGJ, Upper/ Middle, Lower | 3.03 | 1.08-8.12 | 0.039 | |||
| Maximum primary tumor size | ||||||
| ≥ 5 cm / ≤ 4.9 cm | 1.93 | 0.71-4.86 | 0.183 | |||
| T classification | ||||||
| ≥ 3 / ≤ 2 | 1.28 | 0.51-3.45 | 0.596 | |||
| N classification | ||||||
| ≥ 1 / ≤ 0 | 1.03 | 0.41-2.62 | 0.934 | |||
| Histological type | ||||||
| Intestinal /Diffuse and other | 0.25 | 0.10-0.68 | 0.006 | 0.34 | 0.09-0.72 | 0.008 |
| Liver metastases-related factors | ||||||
| Timing of liver metastases | ||||||
| Metachronous / Synchronous | 0.88 | 0.24-2.25 | 0.786 | |||
| Tumor number | ||||||
| Multiple / Single | 1.61 | 0.59-4.02 | 0.329 | |||
| Tumor distribution | ||||||
| Bilobular / Unilobular | 1.24 | 0.43-3.16 | 0.661 | |||
| Maximum tumor size | ||||||
| ≥ 5 cm / ≤ 4.9 cm | 1.93 | 0.71-4.86 | 0.183 | |||
| Portal vein thrombosis | 2.18 | 0.60-6.30 | 0.210 | |||
| Operative procedures | ||||||
| Synchronous hepatectomy | 0.73 | 0.17-1.83 | 0.650 | |||
| Major hepatectomy | 3.16 | 0.77-9.98 | 0.093 | |||
| Operating time | ||||||
| ≥ 360 min / ≤ 359 min | 1.23 | 0.48-3.17 | 0.654 | |||
| Estimated blood loss | ||||||
| ≥ 1000 mL / ≤ 999 mL | 1.05 | 0.64-2.71 | 0.922 | |||
| Blood transfusion | 0.92 | 0.32-2.39 | 0.881 | |||
| Resection | ||||||
| ≥ R1 / R0 | 1.82 | 0.62-4.82 | 0.256 | |||
| Postoperative factors | ||||||
| Clavien-Dindo classification | ||||||
| ≥ I / ≤ 0 | 1.16 | 0.56-2.14 | 0.646 | |||
| Duration of hospital stay | ||||||
| ≥ 14 days / ≤ 13 days | 0.86 | 0.31-2.26 | 0.776 | |||
| Postoperative chemotherapy | 0.79 | 0.29-1.98 | 0.631 | |||
Abbreviations: BMI, body mass index; ASA, American society of anesthesiologists; AFP, α-fetoprotein; CEA, carcinoembryonic antigen; CA19- 9, carbohydrate antigen 19-9; EGJ, esophagogastric junction; Por, undifferentiated adenocarcinoma; HR, hazard ratios; CI, confidence intervals.