Table 5. Univariate and multivariate analysis of extra-hepatic recurrence.
| Variables | Univariate Analysis |
Multivariate Analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Patient factors | ||||||
| Sex | ||||||
| Male / Female | 0.56 | 0.02-5.13 | 0.630 | |||
| Age | ||||||
| ≥ 70 years / ≤ 69 years | 0.57 | 0.11-2.52 | 0.463 | |||
| BMI | ||||||
| ≥ 25.0 kg/m2 / ≤ 24.9 kg/m2 | 0.82 | 0.16-3.26 | 0.363 | |||
| ASA | ||||||
| ≥ 2 / ≤ 1 | 1.03 | 0.52-2.82 | 0.623 | |||
| AFP | ||||||
| ≥ 9.0 IU/mL / ≤ 8.9 IU/mL | 3.00 | 0.46-26.7 | 0.256 | |||
| CEA | ||||||
| ≥ 5.0 IU/mL / ≤ 4.9 IU/mL | 0.53 | 0.09-2.64 | 0.449 | |||
| CA19-9 | ||||||
| ≥ 37.0 IU/mL / ≤ 36.9 IU/mL | 1.50 | 0.31-7.66 | 0.610 | |||
| Preoperative chemotherapy | 2.66 | 0.57-15.0 | 0.213 | |||
| Primary cancer-related factors | ||||||
| Tumor location | ||||||
| EGJ, Upper/ Middle, Lower | 0.30 | 0.05-1.48 | 0.140 | |||
| Maximum primary tumor size | ||||||
| ≥ 5 cm / ≤ 4.9 cm | 1.67 | 0.26-2.46 | 0.253 | |||
| T classification | ||||||
| ≥ 3 / ≤ 2 | 1.54 | 0.33-7.11 | 0.568 | |||
| N classification | ||||||
| ≥ 1 / ≤ 0 | 0.47 | 0.09-2.06 | 0.318 | |||
| Histological type | ||||||
| Intestinal /Diffuse and other | 0.14 | 0.02-0.67 | 0.006 | 0.13 | 0.02-0.66 | 0.012 |
| Liver metastases-related factors | ||||||
| Timing of liver metastases | ||||||
| Metachronous / Synchronous | 3.03 | 0.69-14.5 | 0.141 | |||
| Tumor number | ||||||
| Multiple / Single | 1.07 | 0.20-6.27 | 0.943 | |||
| Tumor distribution | ||||||
| Bilobular / Unilobular | 2.30 | 0.42-18.1 | 0.345 | |||
| Maximum tumor size | ||||||
| ≥ 5 cm / ≤ 4.9 cm | 1.08 | 1.02-5.06 | 0.049 | |||
| Operative procedures | ||||||
| Synchronous hepatectomy | ||||||
| Major hepatectomy | 1.77 | 0.27-11.4 | 0.531 | |||
| Operating time | ||||||
| ≥ 360 min / ≤ 359 min | 1.08 | 0.20-4.14 | 0.919 | |||
| Estimated blood loss | ||||||
| ≥ 1000 mL / ≤ 999 mL | 1.23 | 0.13-4.07 | 0.803 | |||
| Blood transfusion | 1.55 | 0.32-8.91 | 0.589 | |||
| Resection | ||||||
| ≥ R1 / R0 | 2.67 | 0.54-14.0 | 0.221 | |||
| Postoperative factors | ||||||
| Clavien-Dindo classification | ||||||
| ≥ I / ≤ 0 | 0.72 | 0.20-3.08 | 0.654 | |||
| Duration of hospital stay | ||||||
| ≥14 days / ≤13 days | 1.94 | 0.43-9.61 | 0.387 | |||
| Postoperative chemotherapy | 2.40 | 0.55-11.1 | 0.241 | |||
Abbreviations: BMI, body mass index; ASA, American society of anesthesiologists; AFP, α-fetoprotein; CEA, carcinoembryonic antigen; CA19- 9, carbohydrate antigen 19-9; EGJ, esophagogastric junction; Por, undifferentiated adenocarcinoma; OR, odds ratio; CI, confidence intervals.