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. 2020 Dec 7;21(23):9329. doi: 10.3390/ijms21239329

Figure 1.

Figure 1

Inflammatory cytokines decrease PPARγ expression in macrophages. (A) Basal mRNA expression of LXR- and PPAR-isoforms in monocytes from age- and gender-matched healthy controls and relapsing-remitting multiple sclerosis (MS) patients (n = 15). (B) Gene expression of LXR- and PPAR-isoforms in monocyte-derived macrophages (MDMs) from healthy controls stimulated with IFNγ/IL1β (n = 11). (C) Gene expression of LXR- and PPAR-isoforms in MDMs from healthy controls stimulated with IFNγ or IL1β compared to nonstimulated cells (n = 4). RR-MS = relapsing-remitting MS patient; NR = nuclear receptor. Values represent the mean ± S.E.M. Statistical significance (A,B; unpaired Student’s t-test, and C; one-way ANOVA with Dunn’s multiple comparison correction) is indicated with asterisks: * p ≤ 0.05, ** p ≤ 0.01, and *** p ≤ 0.001. n represents the total number of donors included in the experiment.