Figure 3.

Beneficial effects of exercise and Cisd2 overexpression delay aging. Exercise induces expression of Cisd2, as well as other mitochondrial proteins, in skeletal muscle. Both exercise and Cisd2 overexpression lead to improved mitochondrial function, greater muscle strength and reduced aging-associated muscle loss. They further bring about a reversal of the systemic metabolism and body composition changes associated with aging and return the mice to a status closer to that of young individuals. Taking the evidence together, it seems that exercise and Cisd2 activation are two very promising strategies as an individual ages to build a healthy lifespan.