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. 2020 Dec 11;39:280. doi: 10.1186/s13046-020-01790-w

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Screening and expression of hsa_circ_0001829 in gastric cancer cells. a Volcano plot of the differentially expressed circRNAs in GES-1-T and GES-1-N cells (FC ≥ 2 or FC ≤ 0.5 and P < 0.05). Significantly upregulated circRNAs are indicated in red and downregulated circRNAs are indicated in green. The blue arrow indicates hsa_circ_0001829. b Heat map of the differentially expressed circRNAs in GES-1-T and GES-1-N cells. Red indicates a higher fold-change and blue indicates a lower fold-change. c Expression of the top 10 upregulated circRNAs in GES-1-T compared with GES-1-N cells was detected via qRT-PCR. d Expression of hsa_circ_0001829 in four gastric cell lines compared with GES-1-N cells. e Expression of hsa_circ_0001829 in 20 patients with GC (P < 0.0001) and in a tissue microarray of 83 GC paired patients (P < 0.0001). f The genomic loci of the SLC45A4 gene and hsa_circ_0001829. Red arrow indicates the back-splicing of hsa_circ_0001829 confirmed by Sanger sequencing. f qRT-PCR analysis of hsa_circ_0001829 and SLC45A4 mRNA after treatment with RNase R in GES-1-T cells. g The abundance of hsa_circ_0001829 and SLC45A4 mRNA was, respectively, tested by qRT-PCR in GES-1-T cells treated with Actinomycin D at the indicated time points. *p < 0.05, **p < 0.01