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. 2020 Dec 11;8:29. doi: 10.1186/s40170-020-00235-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — a Glutamine enrichment in bone marrow plasma after 60 min of the [¹³C₅]-glutamine infusion in patients with MGUS (N = 11) and MM (N = 12). Error bars represent SEM. n.s. is non-significant by unpaired t test. b Comparison of mean relative ¹³C fractional enrichment of TCA cycle intermediates in CD138+ and CD138- cells from the bone marrows of MGUS (N = 10) and MM (N = 11). Error bars represent SEM. n.s. is non-significant, *p < 0.05, **p < 0.01, and ***p < 0.001 by paired t test. c Relative ¹³C fractional enrichment (CD138+/CD138-) of TCA cycle intermediates from each MGUS (N = 10) and MM (N = 11) patient.