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. 2020 Dec 11;8:29. doi: 10.1186/s40170-020-00235-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — a Violin plots comparing the median concentrations of different TCA metabolites in the bone marrow plasma between MGUS (N = 11) and MM (N = 12) groups. Data was analyzed by Mann-Whitney U test where ***p < 0.001, **p < 0.01, *p < 0.05, ^#p < 0.1 but ≥ 0.05, n.s. non-significant. b Violin plots comparing the median concentrations of different TCA metabolites in the peripheral blood plasma between MGUS (N = 11) and MM (N = 12) groups. Data was analyzed by Mann-Whitney U test where ***p < 0.001, **p < 0.01, *p < 0.05, ^#p < 0.1 but ≥ 0.05, n.s. non-significant. c Violin plots comparing the median concentrations of aspartate and glutamate in the bone marrow plasma between the volunteers (N = 7), MGUS (N = 11), and MM (N = 12) groups. Data was analyzed by Mann-Whitney U test where ***p < 0.001, **p < 0.01, *p < 0.05, ^#p < 0.1 but ≥ 0.05, n.s. non-significant. d XY-correlation plots comparing the concentrations of aspartate and glutamate in the bone marrow plasma of patients with MGUS and MM and the percentage of clonal plasma cells in their bone marrow