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. 2020 Dec 11;8:29. doi: 10.1186/s40170-020-00235-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — a Immunohistochemical staining of the bone marrow for CD138+ clonal plasma cells in MM patient #2 with primary plasma cell leukemia as well as peripheral smear evaluation demonstrating the presence of circulating plasma cells. b Positron emission tomography-computed tomography (PET/CT) demonstrating the presence of a large plasmacytoma in the right chest wall as well as immunohistochemical staining of the bone marrow for CD138+ clonal plasma cells in MM patient #7 with no marrow involvement. c Graphical visualization of the concentrations of the TCA cycle intermediate such as glutamate, succinate, fumarate, malate, and aspartate in the bone marrow plasma of MM patient #2 with primary plasma cell leukemia and MM patient #7 with respect to that of the remainder of the MM patients (represented by the mean (dashed line) and maximum and minimum (dotted lines) values)