Table 2.
Seven genome-wide significant CpG sites (P value < 1.14 × 10–7) of ClinR in relation to methylation in whole blood
| CpG | CHR | Great annotation (distance to TSS) | Discovery | Replication-EGEA | Replication-Lifelines | Meta-analysis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coef | SE | P | N | Coef | SE | P | Nb | Coef | SE | P | N | P.meta | Direction | |||
| cg10125195 | 12 | LACRT (+ 133) | 1.32E−02 | 2.30E−03 | 9.03E−09 | 72 | 1.098 | 0.748 | 0.142 | 80 (69/11) | 2.73E−04 | 3.56E−03 | 0.939 | 124 | 1.58E−04 | + + + |
| cg12713893 | 18 | SNRPD1 (+ 44) | 4.64E−03 | 8.63E−04 | 7.52E−08 | 72 | 7.127 | 5.359 | 0.184 | 120 (106/14) | 4.19E−04 | 1.11E−03 | 0.705 | 124 | 2.90E−04 | + + + |
| cg15404785 | 14 | TRMT5 (− 279,717); TMEM30B (+ 20,765) | − 3.09E−02 | 5.17E−03 | 2.43E−09 | 72 | 0.423 | 0.150 | 0.005 | 105 (93/12) | − 4.93E−03 | 6.11E−03 | 0.420 | 124 | 7.58E−02 | − + − |
| cg27252019 | 17 | MKS1 (+ 550) | − 3.86E−02 | 7.24E−03 | 1.01E−07 | 72 | − 0.033 | 0.269 | 0.902 | 91 (80/11) | 5.71E−03 | 1.01E−02 | 0.572 | 124 | 1.80E−02 | – + |
| cg06185924 | 10 | ACBD5 (− 42) | 1.10E−02 | 2.06E−03 | 9.36E−08 | 72 | NA | NA | NA | 106 (92/14) | − 4.72E−03 | 2.33E−03 | 0.043 | 124 | 1.05E−01 | + NA− |
| cg13378519a | 1 | PEX11B (+ 18) | − 5.99E−03 | 1.07E−03 | 2.43E−08 | 72 | NA | NA | NA | 119 (105/15) | − 1.08E−02 | 2.61E−03 | 3.57E-05 | 124 | 2.58E−11 | −NA− |
| cg17900884 | 1 | ICMT (− 91) | 3.58E−03 | 6.28E−04 | 1.15E−08 | 72 | NA | NA | NA | 114 (101/13) | − 1.78E−04 | 9.86E−04 | 0.857 | 124 | 9.16E−04 | + NA− |
P.meta: the P value of meta-analysis of results from discovery, EGEA and Lifelines by using weighted Z-score method
Direction: the direction of regression coefficient in discovery, EGEA and Lifelines
NA: the result for this probe was not available in EGEA
aThe CpG site was replicated with meta P value < 1.14 × 10–7
bN (persA/ClinR), N varies from one CpG to another because of the methylC-capture sequencing method used and QC criteria in EGEA