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Overview of (1) clinical opportunities for nucleic acid nanoparticles (NANP) therapeutics include small interfering RNAs, antisense oligonucleotides, mRNAs, CRISPR ribonucleoproteins, and vaccine vectors; (2) translational barriers that are limiting progress from academia to the clinic to benefit patients; (3) proposed strategy to overcome these translational barriers; and (4) our recommendation of a consortium to help translate NANPs to the clinic.
