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. Author manuscript; available in PMC: 2020 Dec 11.
Published in final edited form as: J Med Chem. 2020 Jun 18;63(13):7033–7051. doi: 10.1021/acs.jmedchem.0c00366

Scheme 6. Synthesis of 23–27α.

Scheme 6.

αReagents and conditions: (a) 23: DMF, DIPEA, HOBt, EDCI, 25 °C, 2 h. 24,25: HOBt, EDCI, DIPEA, DMF, 25 °C, 1 h; 26: T3P, TEA, DMF, 25 °C, 1 h; 27: DIPEA, DCM, 25 °C, 1 h;