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. Author manuscript; available in PMC: 2020 Dec 11.
Published in final edited form as: J Med Chem. 2020 Jun 18;63(13):7033–7051. doi: 10.1021/acs.jmedchem.0c00366

Figure 3.

Figure 3.

Diastereomer-selective MFN2 conformational switching by 13. A. FRET emission spectra of MFN2 in open active (white) and closed inactive (black) conformation. Schematic to the right depicts FRET-labelled MFN2 protein in closed (top) and open (bottom) conformations. C is N-terminus fluorphore cerulean; V is C-terminus fluorophore mVenus. B. FRET analysis of conformational switching provoked by mitofusin activators. “Peptide” is MP1 mitofusin agonist peptide described in reference17 and depicted in Fig 1A inset, used as a positive control. Data are mean ± SEM of six experiments.