Scheme 1. Synthesis of 1 and Its Backbone Variantsα.
αReagents and conditions: (a) tert-butyl (2-hydroxyethyl)carbamate, DEAD, PPh3, THF, r.t., 1h. (b) HCl/Dioxane, r.t., 18 h. (c) 1 and 2: DCM, r.t., 18 h, 3: DCM, r.t., 30 min.
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