. Author manuscript; available in PMC: 2020 Dec 11.

Published in final edited form as: J Med Chem. 2020 Jun 18;63(13):7033–7051. doi: 10.1021/acs.jmedchem.0c00366

Table 3.

Fusogenic potency and pharmacokinetic properties of 8 analogs lacking the triazol ring^α

Cpd	EC50 (nM)	t1/2 HLM (min)	t1/2 MLM (min)	PAMPA-BBB Pe (nm/sec)
8	5.26 (3.12–8.37)	8	28	10.29
10	383.16 (105.66-ND)	13.3	1.9	160
11	9.95 (6.99–14.05)	40.1	24.2	15.7
12	40.84 (21.44–71.75)	>145	>145	7.96
13	8.18 (6.55–10.15)	>145	92.4	26.28

^α

EC₅₀ values are mean with 95% confidence limits.