Table 3.
Correlation between the IDO concentration and ratio of pro-/anti-inflammatory cytokines in PHA-stimulated PBMC supernatant from normoglycemic participants and T2DM patients.
| Parameter | Normoglycemic participants (n = 13) |
T2DM patients with higher IDO production (n = 9) |
T2DM patients with reduced IDO production (n = 11) |
|||
|---|---|---|---|---|---|---|
| r | P | r | P | r | P | |
| TNF-α/IL-10 ratio | −0.003 | .496 | 0.383 | .154 | −0.155 | .325 |
| IL-6/IL-10 ratio | 0.340 | .128 | 0.683 | .021* | 0.127 | .355 |
| Interferon-γ/IL-10 ratio | 0.440 | .066 | 0.517 | .077 | 0.009 | .489 |
Abbreviations: IDO, indoleamine 2,3-dioxygenase; TNF-α, tumor necrosis factor-α; IL-6, interleukin 6; IL-10, interleukin 10; T2DM, type 2 diabetes mellitus.
All correlations were calculated using Spearman correlations.
*P < .05.