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. 2020 Dec 11;10:144. doi: 10.1186/s13578-020-00506-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Inhibition of xenograft tumor proliferation by in vivo treatment with ATP13A2 siRNA. a Gel retardation assay shows the effects of using different ratios of DOTAP and siATP13A2. b Nude mice (n = 3) were implanted with SW480 cells, and after 10 days, the mice were treated with siNC or siATP13A2 mixed with DOTAP. Bioluminescence (Left panel) and qualification (Right panel) images of tumors in these mice at 20 day after incubation were shown. c Representative image and quantitative analysis of weight of the xenograft tumor were shown when mice were sacrificed. d Representative images (Left panel) and quantification (Right panel) of SOX2, OCT4, LC3, and ATP13A2 in xenograft tumors treated with siNC or siATP13A2 mixed with DOTAP (n = 3). *, P < 0.05; **, P < 0.01; ***, P < 0.01; ns, no significant