Table 1.
Cox Proportional hazards model risk factors associated with time to collecting a prescribed medication
| Hazard Ratio (95% Confidence Interval) | Statistical significance (p-value) | |
|---|---|---|
| Season | ||
| Spring | {reference} | |
| Summer | 0.967 (0.944–0.991) | 0.008 * |
| Autumn | 0.981 (0.958–1.005) | 0.123 |
| Winter | 1.003 (0.979–1.028) | 0.791 |
| Drug Class | ||
| SABA | 1.433 (1.387–1.479) | < 0.001 * |
| LABA | 0.938 (0.890–0.990) | 0.019 * |
| ICS | {reference} | |
| ICS + LABA | 1.067 (1.033–1.102) | < 0.001 * |
| Cromoglicate | 0.778 (0.389–1.558) | 0.479 |
| Immuno-suppressants | 1.244 (1.100–1.408) | < 0.001 * |
| LAMA | 1.349 (1.161–1.567) | < 0.001 * |
| LTRA | 1.350 (1.289–1.414) | < 0.001 * |
| Theophylline | 1.040 (0.897–1.205) | 0.604 |
| Oral steroids | 1.839 (1.743–1.940) | < 0.001 * |
| Previously unclaimed medications | ||
| Low tertile | {reference} | |
| Mid tertile | 0.565 (0.553–0.577) | < 0.001 * |
| High tertile | 0.198 (0.193–0.204) | < 0.001 * |
| Quantity of doses prescribed | 1.000 ** (1.000–1.000) | < 0.001 * |
Statistically significant variables (using a threshold of p = 0.05) are denoted by a star (*)
** Coefficient 0.9999 to four decimal places, and therefore lower than the reference value