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. 2020 Dec 10;15:72. doi: 10.1186/s13024-020-00419-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Microgliosis in the cerebral cortex of IN-PS cDKO mice. a Left: Iba1 immunostaining of comparable sagittal sections in the neocortex of IN-PS cDKO and littermate control brains at 9 months of age. Inserts show higher power views of the boxed areas. Right: Stereological quantification shows significant age-dependent increases in the number of Iba1-immunoreactive cells in the neocortex of IN-PS cDKO mice relative to control mice (Control: 86.17 ± 2.90 cells/mm², cDKO: 152.40 ± 4.34 cells/mm², p < 0.0001, Student’s t-test). b Left: Iba1 immunostaining of comparable sagittal sections in the hippocampus of IN-PS cDKO and littermate control brains at 9 months of age. Inserts show higher power views of the boxed areas. Right: Stereological quantification shows significant age-dependent increases in the number of Iba1-immunoreactive cells in the neocortex of IN-PS cDKO mice relative to control mice (Control: 73.70 ± 4.64 cells/mm², cDKO: 139.00 ± 9.97 cells/mm², p < 0.0001, Student’s t-test). Scale bar: 100 μm. All data represent mean ± SEM. **** p < 0.0001. The value in the column indicates the number of mice used in each experiment