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. Author manuscript; available in PMC: 2020 Dec 11.
Published in final edited form as: Adv Ther (Weinh). 2019 Sep 26;2(11):1900095. doi: 10.1002/adtp.201900095

Figure 2.

Figure 2.

The design of an IME-responsive and biofunctional nanoparticle (NP), and the targeted delivery of nanotherapeutics at a site of infection. (A) A drug-loaded polymeric micelle is self-assembled from pH/enzyme-responsive amphiphilic block copolymers and drugs, followed by an antibody coating to target the infection sites. The poly (ß-amino ester) (PAE) segment is pH-sensitive and enzyme-responsive. The 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)] (PEGylated DSPE) on the pendants of PAE is used for drug loading. Biotins on the surface of a micelle are used for biofunctionalization. (B) Drug-loaded NPs-anti-ICAM-1 specifically target activated endothelial cells at a site of infection after intravenous (i.v.) injection. Drug-loaded NPs-anti-ICAM-1 bind to the activated endothelial cells in IMEs, crossing the blood vessel and releasing drugs triggered by the local infectious cues. Copyright 2018 Wiley.