Simplified metabolism of vitamin D. Vitamin D3 is synthesised in the skin from 7-dehydrocholesterol, hydroxylated to 25(OH)D3 in the liver, and converted to 1,25(OH)2D3 in the kidney. 25(OH)D3 and 1,25(OH)2D are converted by 24(OH)ase to 24,25(OH)2D and 1,24,25(OH)3D.
blue arrows, enzyme pathways; green arrows, pathway activation/inhibition.