. 2020 Jul 27;103(5):927–937. doi: 10.1093/biolre/ioaa128

Table 2.

Differentially expressed AhR-regulated genes in male and female HUVECs from NT and PE¹

Genes in the AhR network	Gene ID	NT-M/NT-F		F_PE/NT		M_PE/NT
Genes in the AhR network	Gene ID	Log2(Fold change)	FDR-adjusted P-value	Log2(Fold change)	FDR-adjusted P-value	Log2(Fold change)	FDR-adjusted P-value
DNAJB1	ENSG00000132002	*−4.35*	*0.000*	*−4.18*	*0.007*	3.61	0.001
HSPH1	ENSG00000120694	*−2.61*	*0.001*	*−2.43*	*0.039*	2.38	0.007
COL1A1	ENSG00000108821	*−2.78*	*0.003*	0.01	1.000	3.13	0.000
GAS1	ENSG00000180447	*−2.79*	*0.015*	−0.74	1.000	3.18	0.005
ITGAM	ENSG00000169896	*−3.50*	*0.001*	−2.26	0.197	2.86	0.019
PCDH8	ENSG00000136099	*−7.11*	*0.002*	−4.85	0.150	6.03	0.047
GSTM5	ENSG00000134201	*−5.11*	*0.004*	*−7.42*	*0.007*	2.27	0.463
COL4A1	ENSG00000187498	2.37	0.001	2.88	0.014	−0.33	1.000
MT2A	ENSG00000125148	1.44	0.024	2.14	0.006	0.10	1.000
COL4A2	ENSG00000134871	2.70	0.001	3.43	0.004	−0.15	1.000
COL11A1	ENSG00000060718	−1.92	0.062	*−2.77*	*0.049*	2.22	0.237
JUNB	ENSG00000171223	0.67	0.553	2.18	0.001	1.06	0.309
CASP8	ENSG00000064012	−0.44	0.826	*−2.19*	*0.003*	−0.95	0.530
SOD2	ENSG00000112096	1.49	0.239	3.09	0.003	1.10	0.875
IRF1	ENSG00000125347	0.09	1.000	1.51	0.040	0.41	1.000
CCL21	ENSG00000137077	−1.69	0.318	*−3.56*	*0.044*	0.98	1.000
CDH2	ENSG00000170558	2.33	0.050	2.76	0.044	−0.74	1.000
SERPINE1	ENSG00000106366	0.94	0.073	1.44	0.026	−0.37	1.000
HEY2	ENSG00000135547	−0.17	1.000	*−4.22*	*0.041*	−0.41	1.000
SOCS3	ENSG00000184557	0.63	0.481	1.34	0.017	0.24	1.000
CXCL10	ENSG00000169245	−0.55	1.000	5.59	0.001	0.43	1.000
SREBF1	ENSG00000072310	0.90	0.122	1.59	0.006	0.22	1.000
EMILIN1	ENSG00000138080	1.40	0.057	2.10	0.007	0.08	1.000
HSP90AA1	ENSG00000080824	*−2.24*	*0.003*	−2.00	0.085	*1.91*	*0.050*
TSPYL2	ENSG00000184205	*−2.29*	*0.003*	−1.89	0.117	2.17	0.052
HSPA5	ENSG00000044574	*−1.90*	*0.010*	−1.61	0.173	1.68	0.080
SIRT1	ENSG00000096717	*−1.38*	*0.018*	−0.99	0.373	1.45	0.114
TGFB2	ENSG00000092969	*−1.24*	*0.033*	0.58	1.000	1.43	0.120
CEBPA	ENSG00000245848	*−3.00*	*0.028*	−3.19	0.153	2.30	0.132
PPP1R15A	ENSG00000087074	*−1.97*	*0.007*	−1.60	0.132	1.84	0.137
FZD7	ENSG00000155760	*−2.74*	*0.015*	−2.79	0.099	2.48	0.141
ASPN	ENSG00000106819	*−2.96*	*0.031*	−1.98	0.400	3.19	0.170
ITGA7	ENSG00000135424	*−3.04*	*0.005*	−3.20	0.071	2.25	0.196
HP	ENSG00000257017	*−2.46*	*0.033*	−2.13	0.320	1.95	0.203
TNF	ENSG00000232810	*−3.44*	*0.009*	−2.25	0.442	2.20	0.243
ESR1	ENSG00000091831	*−2.75*	*0.002*	−2.36	0.081	1.82	0.280
CYP2B6	ENSG00000197408	*−4.44*	*0.022*	−6.27	0.054	3.13	0.297
DIO1	ENSG00000211452	*−2.71*	*0.046*	−2.37	0.253	2.79	0.344
GADD45A	ENSG00000116717	*−1.25*	*0.049*	−0.72	0.635	1.21	0.431
LYST	ENSG00000143669	*−1.50*	*0.022*	−1.30	0.317	1.03	0.533
CDKN2C	ENSG00000123080	*−2.38*	*0.006*	−2.35	0.065	0.80	1.000
RDH16	ENSG00000139547	*−2.32*	*0.040*	−1.66	0.529	0.79	1.000

¹RNAseq dataset (NCBI GEO: GSE116428 [27] was reanalyzed. FDR: false discovery rate; NT-F and NT-M (n = 8); PE-F (n = 5); PE-M (n = 6); bold letters: upregulated genes in the comparison; bold italic letters: downregulated genes in the comparison; FDR-adjusted P < 0.05 is considered significant.