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. Author manuscript; available in PMC: 2020 Dec 11.

Published in final edited form as: Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):519–536. doi: 10.1080/15257770903053979

SCHEME 2 — Reagents and conditions: f) AcOH/Ac₂O/concn. H₂SO₄ (77%); g) TMS-Br/CDCl₃, 2 weeks, room temperature; (13, ≈50%); h) 13/Na-salt of N^6BzAde/THF, reflux, 5 hours (14, 23%; 15, 9%); h) 11/Na-salt of 2,6-di-Cl purine/CH₃CN, room temperature (1:1.04), 18 hours (16+17, 48%); i) saturated NH₃/1,2-DME, room temperature (18, 67%; 19, 25%); j) saturated NH₃/MeOH, room temperature (20, 88%, 21, 81%, 22, 75%, 23, 80%).