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. Author manuscript; available in PMC: 2020 Dec 11.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Aug 24;29(20):126639. doi: 10.1016/j.bmcl.2019.126639

Scheme 2. Reagents and conditions:

Scheme 2.

a) DIPEA, dichloroethane, 70 °C, overnight, for 11a, 67%; for 11b, 74%; for 11c, 56%; for 11d, 45%; b) i) 12, Pd2(dba)3, X-Phos, K3PO4, 2-methylTHF/H2O, 110 °C, overnight, 45–70%; ii) LiOH, THF, 70 °C, 48 h, for 13a, 50%; for 13b, 65%; for 13c, 35%; for 13d, 67%.