Table 3. Association of FGF-23 with incident cognitive impairment in the health ABC study.
| FGF-23 | N | N with outcome | Model 1 | Model 2 | Model 3 |
|---|---|---|---|---|---|
| IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | |||
| 3MSE < 80 | |||||
| Continuous (per 2-fold higher) | 2346 | 341 | 1.08 (0.91, 1.29) | 1.08 (0.93, 1.27) | 1.02 (0.88, 1.19) |
| Quartiles | |||||
| < 36 | 590 | 86 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 36–46 | 596 | 73 | 0.93 (0.66, 1.32) | 1.01 (0.71, 1.44) | 0.96 (0.67, 1.37) |
| 47–60 | 594 | 86 | 1.17 (0.85, 1.62) | 1.28 (0.93, 1.77) | 1.22 (0.86, 1.69) |
| > 60 | 566 | 96 | 1.37 (1.00, 1.89) | 1.34 (0.97, 1.87) | 1.23 (0.88, 1.71) |
| Incident DSST score < 1SD | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | ||
| Continuous (per 2-fold higher) | 2277 | 333 | 0.98 (0.83, 1.12) | 0.95 (0.82, 1.11) | 0.95 (0.82, 1.11) |
| FGF-23 Quartiles | |||||
| < 36 | 591 | 82 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 36–46 | 570 | 97 | 1.23 (0.93, 1.62) | 1.21 (0.91, 1.62) | 1.18 (0.88, 1.57) |
| 47–60 | 580 | 74 | 0.90 (0.67, 1.22) | 0.89 (0.66, 1.21) | 0.88 (0.65, 1.20) |
| > 60 | 536 | 80 | 1.08 (0.81, 1.45) | 1.04 (0.77, 1.40) | 1.04 (0.76, 1.43) |
Model 1 = unadjusted analysis.
Model 2 = adjusted for age, sex, race, study site, education, diabetes, cardiovascular disease, hypertension, eGFR and urine ACR.
Model 3 = M2 + calcium, phosphorus, PTH, 25(OH) Vitamin D and klotho.