Table 4. Association of FGF-23 with baseline cognitive vitality test scores.

N = 843 participants	Model 1	Model 2	Model 3
Outcome*	β (95% CI)	β (95% CI)	β (95% CI)
3MS Score	-0.001 (-0.014, 0.012)	-0.002 (-0.012, 0.009)	-0.002 (-0.013, 0.009)
DST score	-0.004 (-0.053, 0.044)	-0.015 (-0.061, 0.031)	-0.013 (-0.060, 0.034)
Verbal Memory
Immediate Recall	-0.011 (-0.053, 0.032)	-0.005 (-0.043, 0.033)	-0.008 (-0.047, 0.031)
Delayed recall	-0.015 (-0.11, 0.08)	0.003 (-0.086, 0.093)	0.003 (-0.089, 0.095)
Psychomotor Speed	0.018 (-0.025, 0.060)	0.018 (-0.018, 0.054)	0.027 (-0.01, 0.063)
Perceptual Speed	-0.006 (-0.060, 0.047)	-0.001 (-0.046, 0.044)	0.003 (-0.043, 0.049)
Depression	-0.011 (-0.0140, 0.118)	-0.032 (-0.163, 0.098)	-0.048 (-0.182, 0.085)
Executive Function
EXIT15	-0.036 (-0.134, 0.061)	-0.039 (-0.123, 0.046)	-0.05 (-0.136, 0.037)
CLOX1	-0.020 (-0.055, 0.015)	-0.021 (-0.056, 0.014)	-0.02 (-0.056, 0.016)

Model 1 = unadjusted analysis.

Model 2 = adjusted for age, sex, race, study site, education, diabetes, cardiovascular disease, hypertension, eGFR and urine ACR.

Model 3 = M2 + calcium, phosphorus, PTH, 25(OH) Vitamin D and klotho.

*All dependent variables were log transformed.

** FGF-23 was log transformed.