Table 5. Association of FGF-23 with annualized relative change in cognitive vitality test scores.
| N = 843 participants | Model 1 | Model 2 | Model 3 |
|---|---|---|---|
| Outcome* | β (95% CI) | β (95% CI) | β (95% CI) |
| 3MS Score | 0.07 (-0.17, 0.31) | 0.03 (-0.21, 0.26) | 0.03 (-0.21, 0.26) |
| DST score | -0.04 (-1.56, 1.48) | 0.06 (-1.43, 1.54) | 0.09 (-1.39, 1.58) |
| Verbal Memory | |||
| Immediate Recall | -0.15 (-1.96, 1.67) | -0.58 (-2.33, 1.17) | -0.55 (-2.33, 1.19) |
| Delayed recall | -0.42 (-1.28, 0.44) | -0.56 (-1.43, 0.31) | -0.54 (-1.42, 0.33) |
| Psychomotor Speed | 0.42 (-0.26, 1.09) | 0.33 (-0.33, 0.98) | 0.34 (-0.33, 0.98) |
| Perceptual Speed | 0.47 (-0.50, 1.45) | 0.33 (-0.62, 1.28) | 0.33 (-0.62, 1.28) |
| Depression | 0.62 (-2.08, 3.32) | 0.45 (-2.24, 3.13) | 0.42 (-2.26, 3.11) |
| Executive Function | |||
| CLOX1 | -0.46 (-1.22, 0.31) | -0.32 (-1.07, 0.42) | -0.32 (-1.07, 0.43) |
Model 1 = unadjusted analysis.
Model 2 = adjusted for age, sex, race, study site, education, diabetes, cardiovascular disease, hypertension, eGFR and urine ACR.
Model 3 = M2 + calcium, phosphorus, PTH, 25(OH) Vitamin D and klotho.
*All dependent variables were log transformed.
** FGF-23 was log transformed.
*** Coefficient interpretation example 3MSE & FGF-23: Every two fold higher FGF-23 is associated with a 0.07% decline in 3MSE score.