. 2020 Dec 11;15(12):e0243632. doi: 10.1371/journal.pone.0243632

Table 5. Effects of compounds 2, 5, 6 and 11 on HDF migration.

Sample	Dose (μM)	Length between scratches (μm)				Rate of cell migration (%)
Sample		Day 0	Day 1	Day 2	Day 3	Day 1	Day 2	Day 3
Control	-	1428.42 ± 9.67	810.57 ± 7.31	423.25 ± 17.24	195.10 ± 8.65	43.25 ± 0.51	70.37 ± 1.21	86.34 ± 0.61
15,16-Epoxy-6α-O-acetyl-8β-hydroxy-19-nor-clero-13(16),14-diene-17,12;18,2-diolide (2)	3	1186.61 ± 28.16	19.42 ± 15.81	119.65 ± 21.68	0.00 ± 0.00	47.80 ± 1.33^a	89.92 ± 1.83^*^,^a	100.00 ± 0.00^*^,^a
	10	1344.33 ± 17.82	783.41 ± 7.23	106.51 ± 53.54	0.00 ± 0.00	41.72 ± 0.54^a	92.08 ± 3.98^*^,^a	100.00 ± 0.00^*^,^a
(+)-Catechin (5)	1	1361.04 ± 5.81	205.66 ± 3.85	0.00 ± 0.00	0.00 ± 0.00	85.24 ± 0.28^*^,^a	100.00 ± 0.00^*^,^a	100.00 ± 0.00^*^,^a
	3	1393.43 ± 22.98	316.82 ± 20.32	0.00 ± 0.00	0.00 ± 0.00	77.26 ± 1.46^*^,^a	100.00 ± 0.00^*^,^a	100.00 ± 0.00^*^,^a
Quercetin (6)	1	1417.45 ± 5.82	815.79 ± 3.77	298.01 ± 16.30	0.00 ± 0.00	42.45 ± 0.27^a	78.98 ± 1.15^*^,^a	100.00 ± 0.00^*^,^a
	3	1414.32 ± 9.96	857.57 ± 11.77	341.37 ± 7.24	0.00 ± 0.00	39.36 ± 0.83^*^,^a	75.86 ± 0.51^*^,^a	100.00 ± 0.00^*^,^a
Myricetin (11)	1	1340.15 ± 16.44	815.79 ± 7.31	266.39 ± 3.47	148.67 ± 6.96	32.26 ± 0.61^*	77.88 ± 0.29^*^,^a	87.66 ± 0.58^*
	3	1204.36 ± 4.55	758.34 ± 1.81	273.62 ± 8.59	151.15 ± 6.58	37.03 ± 0.15^*	77.28 ± 0.71^*^,^a	87.45 ± 0.55^a
A. vera gel (μg/ml)	1	1278.53 ± 8.29	872.72 ± 0.91	447.09 ± 10.02	82.38 ± 41.23	35.73 ± 0.07	67.08 ± 0.74	93.93 ± 3.04
	3	1357.91 ± 24.70	825.19 ± 21.12	256.31 ± 0.65	136.23 ± 10.80	39.23 ± 1.56	81.12 ± 0.05	89.97 ± 0.80

*Statistically significant difference between the control and sample, p < 0.05 (mean ± S.E.M. of three determinations).

^aStatistically significant difference between A. vera gel and the sample, p < 0.05 (mean ± S.E.M. of three determinations).