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. 2020 Dec 11;15(12):e0243815. doi: 10.1371/journal.pone.0243815

Fig 5. Representative cases of the G1 and G4 groups.

Fig 5

(A) The contrast-enhanced ultrasound showed the hyper-vascular tumor in the left lobe of the liver (upper, arrows). The mass showed a decrease of vascularity after combination treatment of sorafenib (SOR) and doxorubicin-loaded microbubble-albumin nanoparticle complex (DOX-MAC) (lower, arrows). (B) One of the G5 group showed the small hyper-vascular tumor in the left lobe of the liver (upper, arrows). The mass showed an increase of tumor volume with hyper-vascularity without any treatment (lower, arrows). (C) The number of brown-colored stained apoptotic cells on TUNEL staining (×400) was a subtle increase in the G1 group (upper, arrowheads) than the G5 group (lower, arrowheads) without statistical significance. (D) The number of brown-colored stained endothelial cells on CD31 staining (×200) decreased in the G1 group (upper, arrowheads) than the G5 group (lower, arrowheads).