Table 1. Serial changes of the tumor volume.

Variable	G1	G2	G3	G4	G5	P-value*
	(N = 12)	(N = 15)	(N = 12)	(N = 11)	(N = 12)
Baseline	10.3 ± 3.0	10.4 ± 1.4	8.5 ± 2.4	10.3 ± 2.9	9.5 ± 4.5	0.568
1-week	13.8 ± 3.9	15.0 ± 2.6	14.8 ± 3.7	17.6 ± 3.4	18.2 ± 6.0	0.178
2-week	16.8 ± 3.8*	19.7 ± 3.2	20.5 ± 7.9	24.5 ± 4.1	27.8 ± 9.9*	0.009

Values are mean ± SD (mm³). G1, doxorubicin-microbubble and sorafanib combination treated group; G2, sorafenib treated group; G3, doxorubicin-microbubble treated group; G4, doxorubicin treated group; G5, untreated control group.

*One-way analysis of variance (ANOVA).