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Pathophysiology of anemia of chronic inflammation
| Increased inflammatory cytokines effect | Consequences on erythropoiesis |
|---|---|
| Increased macrophage activation |
|
| Suppressed erythroid precursor differentiation | Fewer RBC |
| Decreased erythropoietin responsiveness | Fewer erythroid precursors |
| Decreased erythropoietin production | Fewer erythroid precursors |
| Increased circulating hepcidin concentration |
|
