Table 2.

Clinical Characteristics of Multisystem Inflammatory Syndrome in Children: All Six Criteria Must Be Met

Characteristic	Variable
Age	< 21 years
Fever	Documented fever > 38.0°C (100.4°F) for ≥ 24 h or subjective fever lasting ≥ 24 h
Laboratory evidence of inflammation	Elevated C-reactive protein
	Elevated erythrocyte sedimentation rate
	Elevated fibrinogen
	Elevated procalcitonin
	Elevated D-dimer
	Elevated ferritin
	Elevated lactate dehydrogenase
	Elevated interleukin 6
	Elevated neutrophil count
	Reduced lymphocyte count
	Low albumin level
Multisystem involvement	Involvement of 2 or more of the following organ systems:
	Cardiovascular: elevated cardiac enzymes, abnormal echocardiogram
	Respiratory: pneumonia, pulmonary embolism, ARDS
	Renal: renal failure
	Neurologic: seizures, aseptic meningitis, stroke
	Hematologic: coagulopathy
	Gastrointestinal: abdominal pain, vomiting, diarrhea, elevated liver enzymes
	Dermatologic: erythroderma, mucositis, any other rash.
Lack of alternative diagnosis
Recent or current SARS-CoV-2 infection or exposure	Any of the following findings:
	Positive SARS-CoV-2 RT-PCR
	Positive serology
	Positive antigen test
	COVID-19 exposure within 4 weeks prior to onset of symptoms

ARDS = acute respiratory distress syndrome; COVID-19 = coronavirus disease 2019; RT-PCR = real-time polymerase chain reaction; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2.