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. 2020 Nov 4;7(12):2508–2523. doi: 10.1002/acn3.51234

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© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Interpretation of NfL levels in adult and elderly patients. The relative contribution of the primary disease to the overall NfL level is affected by other causes of neuronal damage. This is particularly relevant in the older populations, where aging and comorbidities lead to a substantial variability between individuals. The increase in neuronal damage caused by the primary disease, for example, AD, may be masked by silent damage due to comorbidities. AD, Alzheimer disease; FTD, frontotemporal dementia; MS, multiple sclerosis; NfL, neurofilament light chain; TBI, traumatic brain injury.