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. 2020 Oct 10;12(19):19421–19439. doi: 10.18632/aging.103841

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Copyright: © 2020 Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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AEP inhibitor alleviated TBI-induced memory dysfunction. (A) Experimental design sketch. (B) The mNSS scoring were measured in all groups following mock and TBI surgeries. (C) The open field showed no difference in the total distance covered. (D) Novel object recognition test (NOR) showed the measured recognition index of the new object in 2 hours and 24 hours. (E) Fear conditioning test showed the freezing time for 2 hours and 24 hours. (F–H) Morris water maze (MWM) test: swimming speed was measured (F), the latency to find the hidden platform from day 1-5 (G), and the spatial memory was tested by removing the platform and measuring the time spent in the target quadrant (H).n=10-13. p value significance is calculated from a one-way ANOVA or two-way ANOVA, all data represent mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001 vs TBI group.