| Laboratory findings mean mean ± SD |
|
Tocilizumab treatment |
Conventional treatment |
| Before the tocilizumab |
One week after tocilizumab treatment |
P |
Prior to admission |
One week after hospitalization |
P value |
| White-cell count, ×109/L |
|
7.6±3.7 |
6.6±5.7 |
< 0.0001 |
7.2±3.9 |
7.0±3.8 |
0.571 |
|
<4*10^9 /L |
7/92 |
19/92 |
|
11/89 |
3/89 |
|
|
>10*10^9 /L |
19/92 |
7/92 |
|
8/89 |
6/89 |
|
| Absolute lymphocyte, ×109/L |
|
1.4±3.3 |
1.3±0.6 |
0.1754 |
1.4±0.6 |
1.5±0.7 |
0.008 |
|
<1.1*10^9 /L |
43/92 |
29/92 |
|
36/89 |
15/89 |
|
| C-reactive protein, mg/L |
|
50.8±67.3 |
7.0±22.2 |
< 0.0001 |
23.0±28.7 |
21.0±34.7 |
0.428 |
|
>7 mg/L |
70/92 |
14/92 |
|
51/89 |
31/89 |
|
| Procalcitonin, ng/ml |
|
0.5±2.5 |
0.2±0.5 |
0.0216 |
0.4±1.8 |
0.1±0.2 |
0.326 |
|
>0.05 ng/mL |
52/92 |
21/92 |
|
36/89 |
17/89 |
|
| Interleukin-6, pg/mL |
|
102.1±535.1 |
369.7±778.6 |
< 0.0001 |
29.2±71.6 |
29.4±81 |
0.219 |
|
>7 pg/mL |
86/92 |
91/92 |
|
76/89 |
69/89 |
|
| Maximum temperature, °C |
|
37.4±0.7 |
36.9±0.4 |
< 0.0001 |
36.7±0.6 |
37.1±0.4 |
< 0.0001 |
| Minimum oxygen saturation, % |
|
90.3±8.0 |
93.1±9.9 |
< 0.0001 |
96.0±2.9 |
94.1±4.8 |
< 0.0001 |
| Neutrophils, ×109/L |
|
5.7±3.4 |
4.4±5.4 |
< 0.0001 |
4.8±3.3 |
4.7±3.6 |
0.265 |
|
>6.3 *10^9 /L |
34/92 |
11/92 |
|
16/89 |
11/89 |
|
| Total bilirubin, umol/L |
|
11.9±6.4 |
10.8±10.1 |
0.0026 |
11.6±12.9 |
12.6±19.9 |
0.847 |
|
>20.5 umol/L |
9/92 |
7/92 |
|
5/89 |
4/89 |
|
| Direct bilirubin, umol/L |
|
5.0±3.1 |
4.1±4.7 |
0.0006 |
5±8.2 |
5.6±11.9 |
0.914 |
| Highest respiratory rate |
|
29.2±14.4 |
26.2±19.7 |
0.0011 |
20.3±2.5 |
22.3±2.1 |
< 0.0001 |
| Maximum heart rate |
|
109±21.1 |
95.5±14.9 |
< 0.0001 |
92.1±14.8 |
102.8±15.6 |
< 0.0001 |
| Platelet count, *10^9 /L |
|
220±86.9 |
219.2±83 |
0.5118 |
228.3±96 |
246.5±91 |
0.100 |
|
<125*10^9 /L |
14/92 |
5/92 |
|
10/89 |
6/89 |
|
| Mean platelet volume |
|
10.3±1.2 |
9.9±1.1 |
0.0730 |
10.1±1.2 |
9.9±1.1 |
0.078 |
| Total protein, g/L |
|
61.0±6.9 |
62.4±7.1 |
0.2706 |
65.3±7.1 |
64.2±9.6 |
0.881 |
|
<60 g/L |
46/92 |
28/92 |
|
20/89 |
16/89 |
|
| Albumin, g/L |
|
33.0±4.7 |
35.4±4 |
0.0009 |
36±4.1 |
35.8±4.7 |
0.537 |
|
<34 g/L |
54/92 |
28/92 |
|
23/89 |
28/92 |
|
| Alanine aminotransferase |
|
35.3±29.6 |
47.6±87.9 |
0.5240 |
27.1±26.6 |
30±29.9 |
0.499 |
| Aspartate aminotransferase |
|
26.6±14.3 |
35.3±57.9 |
0.3393 |
29.9±44.3 |
27.5±25.4 |
0.361 |
| Ratio of albumin to globulin |
|
1.2±0.2 |
1.3±0.3 |
0.0177 |
1.2±0.2 |
1.2±0.2 |
0.739 |
| Lactate dehydrogenase |
|
261.9±111.3 |
241.1±82.3 |
0.3729 |
205.4±83.5 |
197.4±47.7 |
0.079 |
| Carbon dioxide combining power |
|
23.8±3.3 |
24.7±2.8 |
0.077 |
24.3±2.5 |
27.5±20 |
0.214 |
| Creatinine, umol/L |
|
78.5±41.9 |
75.9±36.7 |
0.888 |
70±28.4 |
68.6±25.8 |
0.001 |
| Blood urea nitrogen, mmol/L |
|
6.2±3.7 |
10.4±34.1 |
0.8074 |
5.5±2.9 |
6±2.7 |
0.992 |
| Sodium, mmol/L |
|
138.1±14 |
140±3.3 |
0.2887 |
141.5±4.7 |
140.9±3.8 |
0.291 |
| Potassium, mmol/L |
|
4.2±0.5 |
4.4±0.4 |
0.2087 |
4.1±0.5 |
4.2±0.5 |
0.476 |
| Calcium, mmol/L |
|
2.0±0.1 |
2.1±0.1 |
< 0.0001 |
2.1±0.1 |
2.2±0.1 |
0.054 |
| Hypersensitive troponin, ng/L |
|
0.1±0.3 |
0.03±0.08 |
0.3792 |
0±0.2 |
0±0.1 |
0.203 |
| Fibrinogen, g/L |
|
3.7±1.3 |
2.5±0.7 |
< 0.0001 |
3.4±0.7 |
3.6±2.1 |
0.437 |
| D-dimer, mg/L |
|
2.5±3.3 |
2.9±3.7 |
0.1929 |
1.3±1.6 |
1.4±1.2 |
0.069 |
