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. 2020 Dec 9;5(1):e505. doi: 10.1097/HS9.0000000000000505

Figure 2.

Figure 2.

Mediastinal mass, Case 2. (A), Hematoxylin and eosin–stained sections show a high-grade lymphoma with a starry sky pattern and prominent central nucleoli (400×). The tumor cells are CD79 positive (B), CD5 negative (C), BCL2 positive (D), BCL6 positive (E), MYC positive (F), cyclin D1 positive (G), SOX11 negative (H), with high Ki67 proliferation rate (I). The tumor cells were negative for MUM1, TdT, and CD10 (not shown). FISH studies revealed breaks in BCL2 (J), BCL6 (K), CCND1 (L), and MYC (M) in approximately 80% of nuclei. FISH = fluorescence in situ hybridization.