Figure 6. Inactivation of all inflammasomes inhibits CNV lesion formation significantly more than when targeting only NLRP3 or C3.

Comparison of fold-changes in CNV lesion numbers and sizes in all strains relative to Vegfa^hyper mice. 6-weeks-old mice. Vegfa^hyperC3^+/+ mice are littermates of Vegfa^hyperC3^-/- mice that are WT for C3. Graphs show mean ± SEM. Absolute numbers of mice per group are indicated in parentheses. P-values are shown. Kruskal-Wallis test followed by Dunn’s test.