Table 1:
Demographic and clinical characteristics of patients with LPA and PCA
| Features | LPA (N = 77) | PCA (N = 59) | FDR p-values |
|---|---|---|---|
| Gender (female) | 46 (60%) | 36 (61%) | 0.88 |
| Handedness (right) | 68 (88%) | 54 (92%) | 0.68 |
| Age Onset (years) | 64 (57, 70) | 58 (54, 63) | 0.0002 |
| Age MRI (years) | 68 (61, 73) | 62 (58.5, 69.5) | 0.02 |
| Education | 16 (14, 16) | 16 (13, 18) | 0.66 |
| Disease duration (years) | 3.6 (2.7, 4.9) | 4.7 (3.9, 6.8) | 0.0004 |
| Global PiB SUVR | 2.4 (2.2, 2.6) | 2.5 (2.3, 2.6) | 0.29 |
| BNT | 9 (6.5, 12) | 12 (9, 14) | 0.02 |
| BDAE repetition | 6 (4, 8) | 8 (6, 10) | 0.02 |
| NPI-Q | 2 (1, 4) | 3.5 (2, 6) | 0.03 |
| CDR sum of boxes | 3 (1.5, 4.5) | 4 (2, 7.5) | 0.02 |
| WMS-III VR% retention MOANS | 8 (6, 10.5) | 7.5 (4, 9.8) | 0.29 |
| AVLT long term recall MOANS | 6 (4, 7) | 6 (4, 8) | 0.68 |
| VOSP letters | 19.5 (18, 20) | 11.5 (5.25, 16) | <0.0001 |
| MOCA | 16 (10, 19) | 18 (10, 20) | 0.62 |
| MSD-UPDRS III | 3 (1.375, 6) | 2 (0, 8) | 0.29 |
| Rey-O MOANS | 6 (2, 9.25) | 2 (2, 2) | 0.0002 |
Data are shown as Q1 (Q1, Q3) or N (%). Significant adjusted p-values are bolded. AVLT: Auditory Verbal Learning Test, Rey-O-MOANS: Rey Osterrieth Mayo Older American Normative Scale, MOCA: Montreal Cognitive Assessment Battery; CDR: Clinical Dementia Rating, VOSP: visual object and space perception, WMS-III VR% retention MOANS: Wechsler Memory Scale III Visual Reproduction MOANS, BNT: Boston Naming Test, BDAE: Boston Diagnostic Aphasia Examination, NPI-Q: Neuropsychiatric Inventory Brief Questionnaire, MSD-UPDRS III: Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III.