Table 1.
Effects of isolation on 11-months-old male 3xTg-AD mice in the Open field test.
| Males, 11-month-old Ethogram and Emotionality Open field test | NTg (n = 9) | 3xTg-AD mice n = 20 | Statistics | ||
|---|---|---|---|---|---|
| 3xTg-AD (n = 10) | Isolated 3xTg-AD (n = 10) | AD Genotype | Isolation | ||
| Initial freezing (latency, s) | 16.44 ± 12.40 | 17.80 ± 6.08 | 9.00 ± 2.61 | n.s | n.s |
| Exit of the center (latency, s) | 45.22 ± 19.39 | 59.30 ± 31.08 | 22.30 ± 12.65 | n.s | n.s |
| Entrance to the periphery (latency, s) | 68.67 ± 33.11 | 60.60 ± 30.96 | 64.00 ± 28.66 | n.s | n.s |
| Vertical activity (latency, s) | 146.89 ± 41.68 | 131.90 ± 34.67 | 116.40 ± 27.22 | n.s | n.s |
| Thigmotaxis (total crossings periphery/center) | 3.20 ± 0.95 | 3.70 ± 0.88 | 3.80 ± 1.18 | n.s | n.s |
| Self-grooming (latency, s) | 204.00 ± 32.24 | 199.10 ± 36.21 | 162.40 ± 22.27 | n.s | n.s |
| Self-grooming (number) | 1.00 ± 0.29 | 1.20 ± 0.20 | 1.20 ± 0.20 | n.s | n.s |
| Defecation boli (number) | 4.22 ± 0.52 | 3.90 ± 0.58 | 4.50 ± 0.45 | n.s | n.s |
Ethogram, thigmotaxis, self-grooming and defecation. Results are expressed as mean ± SEM. Groups: NTg, group-housed non-transgenic mice; 3xTg-AD, group-housed 3xTg-AD mice; Isolated 3xTg-AD, single-housed 3xTg-AD mice. All n.s., p > 0.05.